DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 185:189

E3 ligase: SPOP

DEGRON score: 0.9295

ASA_SCORE: 88.14

COIL: 0.9278

CONS_SCORE: 0.4534

DSS_SCORE: 0.6364

HELIX: 0.0128

FCONS_SCORE: 1

RIG_SCORE: 0.6528

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E180D	TCGA-A5-A2K5	UCEC	TCGA	AMTSS	DEG_SPOP_SBC_1	0.1944
p.E180D	DO41379	UCEC	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1944
p.T195N	TCGA-P5-A5EV	LGG	TCGA	AMTSS	DEG_SPOP_SBC_1	0.1667
p.T195N	DO50160	LGG	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1667
p.P185L	TCGA-YD-A89C	SKCM	TCGA	AMTSS	DEG_SPOP_SBC_1	0.7582
p.P185L	DO219501	SKCM	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7582
p.T183M	DO224645	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.2778
p.S175P	DO224674	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S175P	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S175P	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S175P	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S175P	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S175P	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.V182F	DO222822	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.V182F	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.25
p.T187I	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7078
p.T187I	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7078
p.T187I	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7078
p.T187I	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7078
p.T187I	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7078
p.T198I	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.5278
p.T198I	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.5278
p.T198I	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.5278
p.T198I	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.5278
p.T198I	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.5278
p.V177M	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229006	LICA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.V177M	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.1111
p.T175K	DO229010	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.T175K	DO229013	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.T175K	DO229016	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.T175K	DO229003	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.T175K	DO229005	COCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.T175K	DO229211	THCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.S189F	DO52680	MALY	ICGC	AMTSS	DEG_SPOP_SBC_1	0.7982
p.P199S	DO220889	MELA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.0556
p.P183S	DO229453	SKCA	ICGC	AMTSS	DEG_SPOP_SBC_1	0.2778
p.T179N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	AMTSS	DEG_SPOP_SBC_1	0.1667
p.T179N	ACH-000929	Lung Cancer	CCLE	AMTSS	DEG_SPOP_SBC_1	0.1667
p.T179N	NCI-H2110	lung	COSMIC	AMTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	185:189	AMTSS	SPOP	0.9295	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	2237:2241	AMTSS	SPOP	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AMTSS

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of AMTSS