DegronMD - O75037(KIF21B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1247C	TCGA-2W-A8YY	CESC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	TCGA-EO-A3AU	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	DO223732	CESC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	DO43827	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	SIDM00795	Melanoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	ACH-000219	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	ACH-002001	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	ACH-002002	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	ACH-002003	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247C	A375	skin	COSMIC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.P1246L	TCGA-30-1714	OV	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1944
p.P1246L	DO30850	OV	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1944
p.R864P	TCGA-43-A475	LUSC	TCGA	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.R864P	DO45431	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.S259W	TCGA-A1-A0SI	BRCA	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.6763
p.S259W	TCGA-LC-A66R	BLCA	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.6763
p.S259W	DO44031	BLCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.6763
p.S259W	DO1774	BRCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.6763
p.D1233V	TCGA-A3-3311	KIRC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.3056
p.R1245Q	TCGA-A6-2686	COAD	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	TCGA-CV-7252	HNSC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	DO7828	COAD	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	DO14176	HNSC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	SIDM00974	Melanoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	ACH-002207	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245Q	WM35	skin	COSMIC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1247H	TCGA-AP-A0LM	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	TCGA-AX-A0J1	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	TCGA-B5-A3FA	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	TCGA-B5-A3FC	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	TCGA-L5-A4OI	ESCA	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	DO232224	PBCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	DO43306	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	DO52402	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	DO41871	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.R1247H	DO41199	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1667
p.A180T	TCGA-AX-A060	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.3056
p.A180T	DO42576	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.3056
p.A180T	SIDM01608	Endometrial Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.3056
p.A180T	ACH-000990	Endometrial/Uterine Cancer	CCLE	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.3056
p.V189I	TCGA-AX-A1CE	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.0556
p.V189I	DO42280	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.0556
p.G182S	TCGA-AX-A1CE	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.25
p.G182S	DO233920	GACA	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.25
p.G182S	DO42280	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.25
p.D845Y	TCGA-DD-A11C	LIHC	TCGA	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.D845Y	DO22917	LIHC	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.D1233N	TCGA-DK-A3X1	BLCA	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.3056
p.D1233N	DO447	BLCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.3056
p.D243N	TCGA-EO-A22U	UCEC	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.0556
p.D243N	DO43755	UCEC	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.0556
p.S857P	TCGA-FI-A2D5	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.S857P	DO41331	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.P842L	TCGA-FR-A726	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.P842L	DO48665	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.D243G	TCGA-IB-7651	PAAD	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.0556
p.D243G	DO46657	PAAD	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.0556
p.K268E	TCGA-MX-A5UJ	STAD	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation substituting flanking lysine	0.2222
p.K268E	DO48547	STAD	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation substituting flanking lysine	0.2222
p.D254N	TCGA-QB-A6FS	SKCM	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.5821
p.D254N	DO48654	SKCM	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.5821
p.G1235E	TCGA-RP-A693	SKCM	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation altering degron motif	0.6087
p.G1235E	DO51268	SKCM	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation altering degron motif	0.6087
p.I174N	TCGA-YF-AA3L	BLCA	TCGA	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.728
p.I174N	DO51951	BLCA	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation altering degron motif	0.728
p.R1250C	DO50311	ESAD	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.0833
p.R864H	DO233210	GACA	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.T187N	DO228985	LICA	ICGC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.S853R	DO228985	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6316
p.S853R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6316
p.S853R	ACH-000843	Lung Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6316
p.S853R	HARA	lung	COSMIC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6316
p.L844M	DO229034	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.P257H	DO229041	LICA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.7694
p.P258L	DO220886	MELA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.6471
p.S851L	DO222662	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.S851L	DO50727	ORCA	ICGC	ASTTS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.N1251K	DO50686	ORCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.0556
p.E263G	DO229259	THCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263G	SIDM00915	Small Cell Lung Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263G	ACH-002173	Lung Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263G	NCI-H378	lung	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.I184M	SIDM02067	Colorectal Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1944
p.E263K	SIDM01106	Melanoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263K	SIDM01578	Bladder Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263K	ACH-000822	Skin Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263K	ACH-000862	Bladder Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.E263K	SK-MEL-24	skin	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.25
p.D166Y	SIDM00965	Small Cell Lung Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.D166Y	ACH-000800	Lung Cancer	CCLE	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.D166Y	NCI-H446	lung	COSMIC	IKIHED	LIG_APCC_ABBA_1	174:179	Mutation rewiring degron network	0.1111
p.S260N	SIDM00375	Head and Neck Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.7069
p.S260N	ACH-002305	Head and Neck Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.7069
p.S260N	SKN-3	upper aerodigestive tract	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation altering degron motif	0.7069
p.L252R	SIDM00534	Colorectal Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.3056
p.L252R	ACH-000986	Colon/Colorectal Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.3056
p.L252R	HT-115	large intestine	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	253:260	Mutation rewiring degron network	0.3056
p.R1245W	SIDM01444	Glioblastoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1245W	ACH-000370	Brain Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.2222
p.R1225Q	ACH-001232	Brain Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.0833
p.N1248S	ACH-002293	Lymphoma	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	1234:1241	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF21B

UniProt ID: O75037

Entrez ID: 23046

Protein name: Kinesin-like protein KIF21B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF21B in