DegronMD

Uniprot ID: O75037

Source protein: Kinesin-like protein KIF21B

Source gene: KIF21B

Class: DEG_SCF_FBW7_1

Location: 253:260

E3 ligase: FBXW7

DEGRON score: 0.8025

ASA_SCORE: 79.6

COIL: 0.9118

CONS_SCORE: 0.2987

DSS_SCORE: 0.5215

HELIX: 0.0599

FCONS_SCORE: 0.6833

RIG_SCORE: 0.6389

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S259W	TCGA-A1-A0SI	BRCA	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.6763
p.S259W	TCGA-LC-A66R	BLCA	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.6763
p.S259W	DO44031	BLCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.6763
p.S259W	DO1774	BRCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.6763
p.D243N	TCGA-EO-A22U	UCEC	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.0556
p.D243N	DO43755	UCEC	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.0556
p.D243G	TCGA-IB-7651	PAAD	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.0556
p.D243G	DO46657	PAAD	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.0556
p.K268E	TCGA-MX-A5UJ	STAD	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.2222
p.K268E	DO48547	STAD	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.2222
p.D254N	TCGA-QB-A6FS	SKCM	TCGA	PDGTPPSS	DEG_SCF_FBW7_1	0.5821
p.D254N	DO48654	SKCM	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.5821
p.P257H	DO229041	LICA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.7694
p.P258L	DO220886	MELA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.6471
p.E263G	DO229259	THCA	ICGC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263G	SIDM00915	Small Cell Lung Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263G	ACH-002173	Lung Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263G	NCI-H378	lung	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263K	SIDM01106	Melanoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263K	SIDM01578	Bladder Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263K	ACH-000822	Skin Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263K	ACH-000862	Bladder Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.E263K	SK-MEL-24	skin	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	0.25
p.S260N	SIDM00375	Head and Neck Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	0.7069
p.S260N	ACH-002305	Head and Neck Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	0.7069
p.S260N	SKN-3	upper_aerodigestive_tract	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	0.7069
p.L252R	SIDM00534	Colorectal Carcinoma	GDSC	PDGTPPSS	DEG_SCF_FBW7_1	0.3056
p.L252R	ACH-000986	Colon/Colorectal Cancer	CCLE	PDGTPPSS	DEG_SCF_FBW7_1	0.3056
p.L252R	HT-115	large_intestine	COSMIC	PDGTPPSS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDGTPPSS

Degron related mutations and impact score

Drug responses associated with KIF21B mutations

All proteins holding degron of PDGTPPSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75037	Kinesin-like protein KIF21B	DEG_SCF_FBW7_1	253:260	PDGTPPSS	FBXW7	0.8025	More...