DegronMD

Uniprot ID: O75037

Source protein: Kinesin-like protein KIF21B

Source gene: KIF21B

Class: DEG_SCF_FBW7_1

Location: 1234:1241

E3 ligase: FBXW7

DEGRON score: 0.9928

ASA_SCORE: 86.4625

COIL: 0.9689

CONS_SCORE: 0.2881

DSS_SCORE: 0.8139

HELIX: 0.014

FCONS_SCORE: 0.9807

RIG_SCORE: 0.5818

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1247C	TCGA-2W-A8YY	CESC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	TCGA-EO-A3AU	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	DO223732	CESC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	DO43827	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	SIDM00795	Melanoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	ACH-000219	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	ACH-002001	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	ACH-002002	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	ACH-002003	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247C	A375	skin	COSMIC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.P1246L	TCGA-30-1714	OV	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1944
p.P1246L	DO30850	OV	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1944
p.D1233V	TCGA-A3-3311	KIRC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.3056
p.R1245Q	TCGA-A6-2686	COAD	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	TCGA-CV-7252	HNSC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	DO7828	COAD	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	DO14176	HNSC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	SIDM00974	Melanoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	ACH-002207	Skin Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245Q	WM35	skin	COSMIC	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1247H	TCGA-AP-A0LM	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	TCGA-AX-A0J1	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	TCGA-B5-A3FA	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	TCGA-B5-A3FC	UCEC	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	TCGA-L5-A4OI	ESCA	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	DO232224	PBCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	DO43306	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	DO52402	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	DO41871	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.R1247H	DO41199	UCEC	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.1667
p.D1233N	TCGA-DK-A3X1	BLCA	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.3056
p.D1233N	DO447	BLCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.3056
p.G1235E	TCGA-RP-A693	SKCM	TCGA	VGFTPPSS	DEG_SCF_FBW7_1	0.6087
p.G1235E	DO51268	SKCM	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.6087
p.R1250C	DO50311	ESAD	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.0833
p.N1251K	DO50686	ORCA	ICGC	VGFTPPSS	DEG_SCF_FBW7_1	0.0556
p.R1245W	SIDM01444	Glioblastoma	GDSC	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1245W	ACH-000370	Brain Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.2222
p.R1225Q	ACH-001232	Brain Cancer	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.0833
p.N1248S	ACH-002293	Lymphoma	CCLE	VGFTPPSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGFTPPSS

Degron related mutations and impact score

Drug responses associated with KIF21B mutations

All proteins holding degron of VGFTPPSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75037	Kinesin-like protein KIF21B	DEG_SCF_FBW7_1	1234:1241	VGFTPPSS	FBXW7	0.9928	More...