DegronMD

Uniprot ID: O75037

Source protein: Kinesin-like protein KIF21B

Source gene: KIF21B

Class: LIG_APCC_ABBA_1

Location: 174:179

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9223

ASA_SCORE: 46.7

COIL: 0.2875

CONS_SCORE: 0.5915

DSS_SCORE: 0.4319

HELIX: 0.0033

FCONS_SCORE: 1.4314

RIG_SCORE: 0.7436

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I174N	TCGA-YF-AA3L	BLCA	TCGA	IKIHED	LIG_APCC_ABBA_1	0.728
p.I174N	DO51951	BLCA	ICGC	IKIHED	LIG_APCC_ABBA_1	0.728
p.A180T	TCGA-AX-A060	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	0.3056
p.A180T	DO42576	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	0.3056
p.A180T	SIDM01608	Endometrial Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	0.3056
p.A180T	ACH-000990	Endometrial/Uterine Cancer	CCLE	IKIHED	LIG_APCC_ABBA_1	0.3056
p.G182S	TCGA-AX-A1CE	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	0.25
p.G182S	DO233920	GACA	ICGC	IKIHED	LIG_APCC_ABBA_1	0.25
p.G182S	DO42280	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	0.25
p.I184M	SIDM02067	Colorectal Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	0.1944
p.T187N	DO228985	LICA	ICGC	IKIHED	LIG_APCC_ABBA_1	0.1111
p.D166Y	SIDM00965	Small Cell Lung Carcinoma	GDSC	IKIHED	LIG_APCC_ABBA_1	0.1111
p.D166Y	ACH-000800	Lung Cancer	CCLE	IKIHED	LIG_APCC_ABBA_1	0.1111
p.D166Y	NCI-H446	lung	COSMIC	IKIHED	LIG_APCC_ABBA_1	0.1111
p.V189I	TCGA-AX-A1CE	UCEC	TCGA	IKIHED	LIG_APCC_ABBA_1	0.0556
p.V189I	DO42280	UCEC	ICGC	IKIHED	LIG_APCC_ABBA_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75037	Kinesin-like protein KIF21B	LIG_APCC_ABBA_1	174:179	IKIHED	APC,CDC20,FZR1	0.9223	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons