DegronMD

Uniprot ID: Q8TEV9

Source protein: Guanine nucleotide exchange protein SMCR8

Source gene: SMCR8

Class: DEG_Kelch_Keap1_1

Location: 465:470

E3 ligase: KEAP1

DEGRON score: 0.9978

ASA_SCORE: 77.3167

COIL: 0.906

CONS_SCORE: 0.397

DSS_SCORE: 0.4385

HELIX: 0.0412

FCONS_SCORE: 1.0964

RIG_SCORE: 0.6712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D459N	TCGA-A5-A0G2	UCEC	TCGA	SISSGE	DEG_Kelch_Keap1_1	0.1667
p.D459N	DO41235	UCEC	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.1667
p.E478D	TCGA-F5-6814	READ	TCGA	SISSGE	DEG_Kelch_Keap1_1	0.1111
p.E478D	DO36556	READ	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.1111
p.T477M	TCGA-SX-A7SN	KIRP	TCGA	SISSGE	DEG_Kelch_Keap1_1	0.1389
p.T477M	DO49786	KIRP	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.1389
p.G469C	DO228978	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.76
p.L475F	DO229041	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.1944
p.E470K	DO229054	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.7022
p.I466F	DO228162	PBCA	ICGC	SISSGE	DEG_Kelch_Keap1_1	0.6304
p.M462V	SIDM00422	Hodgkin's Lymphoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	0.25
p.M462V	ACH-001203	Lymphoma	CCLE	SISSGE	DEG_Kelch_Keap1_1	0.25
p.M462V	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	SISSGE	DEG_Kelch_Keap1_1	0.25
p.D461G	SIDM00600	Thyroid Gland Carcinoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	0.2222
p.D461G	ACH-001528	Thyroid Cancer	CCLE	SISSGE	DEG_Kelch_Keap1_1	0.2222
p.D461G	IHH-4	thyroid	COSMIC	SISSGE	DEG_Kelch_Keap1_1	0.2222
p.S468G	SIDM00333	Endometrial Carcinoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	0.8104
p.S468G	ACH-000988	Endometrial/Uterine Cancer	CCLE	SISSGE	DEG_Kelch_Keap1_1	0.8104
p.S468G	MFE-319	endometrium	COSMIC	SISSGE	DEG_Kelch_Keap1_1	0.8104

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_Kelch_Keap1_1	465:470	SISSGE	KEAP1	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons