DegronMD

Uniprot ID: Q8TEV9

Source protein: Guanine nucleotide exchange protein SMCR8

Source gene: SMCR8

Class: DEG_SCF_FBW7_1

Location: 597:604

E3 ligase: FBXW7

DEGRON score: 0.8356

ASA_SCORE: 82.0625

COIL: 0.917

CONS_SCORE: 0.3652

DSS_SCORE: 0.6921

HELIX: 0.0295

FCONS_SCORE: 0.949

RIG_SCORE: 0.6004

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P598L	TCGA-XF-AAN2	BLCA	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	0.6471
p.P598L	DO219052	BLCA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.6471
p.A602T	TCGA-EO-A22T	UCEC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	0.6028
p.A602T	DO42320	UCEC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.6028
p.S614R	NCI-H1944	lung	COSMIC	LPSTPAHT	DEG_SCF_FBW7_1	0.5
p.E608K	TCGA-A5-A2K5	UCEC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.E608K	DO41379	UCEC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.E608D	DO229008	LICA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.G593C	SIDM00720	Mesothelioma	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.G593C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.G593C	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	0.2222
p.D609Y	DO229031	LICA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.1944
p.S591R	TCGA-QK-AA3J	HNSC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	0.1667
p.S591R	DO52101	HNSC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	0.1667

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SCF_FBW7_1	597:604	LPSTPAHT	FBXW7	0.8356	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons