DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_SPOP_SBC_1

Location: 970:974

E3 ligase: SPOP

DEGRON score: 0.9754

ASA_SCORE: 80.5

COIL: 0.7644

CONS_SCORE: 0.3288

DSS_SCORE: 0.4575

HELIX: 0.1256

FCONS_SCORE: 0.9093

RIG_SCORE: 0.7029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L981R	TCGA-A5-A2K4	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	0.1389
p.R960I	TCGA-AA-3510	COAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.0556
p.R983T	TCGA-KC-A7FA	PRAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.0833
p.S974F	DO219037	BLCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.9093
p.R979C	DO219640	BRCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.R979H	DO222884	COCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.R979H	DO233888	GACA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.H969N	DO229018	LICA	ICGC	VASTS	DEG_SPOP_SBC_1	0.3056
p.P982H	DO229027	LICA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1111
p.R979S	DO24692	LUAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.R979S	DO37823	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.R961G	DO219161	LUSC	ICGC	VASTS	DEG_SPOP_SBC_1	0.5278
p.S973Y	DO41379	UCEC	ICGC	VASTS	DEG_SPOP_SBC_1	0.712
p.R968W	SIDM00966	Ovarian Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.2778
p.R968W	SIDM00217	Colorectal Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.2778
p.R968W	ACH-000999	Colon/Colorectal Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.2778
p.R968W	ACH-002182	Ovarian Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.2778
p.R968W	OVCA433	ovary	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.R968W	SNU-1040	large_intestine	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.E965D	SIDM00628	Breast Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1944
p.G976S	KYSE-520	oesophagus	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.G976S	JHH-2	liver	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.G976S	NY	bone	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.G976S	HuCCT1	biliary_tract	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.G976S	OSC-19	upper_aerodigestive_tract	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778
p.G976S	AN3-CA	endometrium	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons