DegronMD - P55211(CASP9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D330E	TCGA-42-2591	OV	TCGA	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.0833
p.D330E	DO31654	OV	ICGC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.0833
p.S307F	TCGA-EE-A2A2	SKCM	TCGA	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation blocking phosphorylation signal	0.5833
p.S307F	TCGA-EE-A2A2	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	298:302	Mutation blocking phosphorylation signal	0.6389
p.S307F	DO37583	SKCM	ICGC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation blocking phosphorylation signal	0.5833
p.S307F	DO37583	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	298:302	Mutation blocking phosphorylation signal	0.6389
p.S302F	DO222363	MELA	ICGC	VASTS	DEG_SPOP_SBC_1	298:302	Mutation altering degron motif	0.9093
p.D330N	SIDM00973	Melanoma	GDSC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.0833
p.D330N	ACH-000827	Skin Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.0833
p.D330N	WM793B	skin	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.0833
p.E306K	SIDM00874	Breast Carcinoma	GDSC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.1111
p.E306K	SIDM00874	Breast Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.2222
p.E306K	ACH-000223	Breast Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.1111
p.E306K	ACH-000223	Breast Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.2222
p.E306K	HCC1937	breast	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.1111
p.E306K	HCC1937	breast	COSMIC	VASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.2222
p.S310I	ACH-000945	Lung Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation blocking phosphorylation signal	0.6667
p.S310I	ACH-000945	Lung Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	298:302	Mutation blocking phosphorylation signal	0.5556
p.G319A	HEL	haematopoietic and lymphoid tissue	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation altering degron motif	0.754
p.Q316H	GOTO	autonomic ganglia	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation altering degron motif	0.7582
p.H293Y	G-MEL	skin	COSMIC	VASTS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1944
p.F329L	HCC2998	large intestine	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	314:321	Mutation rewiring degron network	0.1111

Kaplan plot for CASP9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASP9

UniProt ID: P55211

Entrez ID: 842

Protein name: Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASP9 in