DegronMD

Uniprot ID: P55211

Source protein: Caspase-9

Source gene: CASP9

Class: DEG_SCF_FBW7_2

Location: 314:321

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 79.4

COIL: 0.7378

CONS_SCORE: 0.4649

DSS_SCORE: 0.784

HELIX: 0.2259

FCONS_SCORE: 1.2088

RIG_SCORE: 0.6726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D330E	TCGA-42-2591	OV	TCGA	PDATPFQE	DEG_SCF_FBW7_2	0.0833
p.D330E	DO31654	OV	ICGC	PDATPFQE	DEG_SCF_FBW7_2	0.0833
p.S307F	TCGA-EE-A2A2	SKCM	TCGA	PDATPFQE	DEG_SCF_FBW7_2	0.5833
p.S307F	DO37583	SKCM	ICGC	PDATPFQE	DEG_SCF_FBW7_2	0.5833
p.D330N	SIDM00973	Melanoma	GDSC	PDATPFQE	DEG_SCF_FBW7_2	0.0833
p.D330N	ACH-000827	Skin Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	0.0833
p.D330N	WM793B	skin	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	0.0833
p.E306K	SIDM00874	Breast Carcinoma	GDSC	PDATPFQE	DEG_SCF_FBW7_2	0.1111
p.E306K	ACH-000223	Breast Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	0.1111
p.E306K	HCC1937	breast	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	0.1111
p.S310I	ACH-000945	Lung Cancer	CCLE	PDATPFQE	DEG_SCF_FBW7_2	0.6667
p.G319A	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	0.754
p.Q316H	GOTO	autonomic_ganglia	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	0.7582
p.F329L	HCC2998	large_intestine	COSMIC	PDATPFQE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55211	Caspase-9	DEG_SCF_FBW7_2	314:321	PDATPFQE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons