DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: DEG_APCC_DBOX_1

Location: 554:562

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9844

ASA_SCORE: 92.6778

COIL: 0.6677

CONS_SCORE: 0.2756

DSS_SCORE: 0.4701

HELIX: 0.1563

FCONS_SCORE: 1.0339

RIG_SCORE: 0.7541

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S557I	SK-OV-3	ovary	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.7341
p.R555Q	TCGA-EO-A22R	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	0.7329
p.P562S	DO23370	LINC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	0.6752
p.P558S	DO37406	SKCM	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	0.6752
p.P558S	NCI-H146	lung	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.6752
p.P558S	COLO-678	large_intestine	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.6752
p.P559S	Mewo	skin	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.6752
p.R564Q	DO38288	STAD	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	0.2778
p.R564Q	DO43755	UCEC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	0.2778
p.R550Q	TCGA-BR-8078	STAD	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	0.2222
p.R550Q	TCGA-EO-A22U	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	0.2222
p.R569Q	DO42713	UCEC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	0.1389
p.N570H	SIDM01611	Endometrial Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	0.1111
p.N570H	ACH-000996	Endometrial/Uterine Cancer	CCLE	QRRPLAVLK	DEG_APCC_DBOX_1	0.1111
p.P545S	SIDM00545	Melanoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0833
p.P545S	ACH-000987	Skin Cancer	CCLE	QRRPLAVLK	DEG_APCC_DBOX_1	0.0833
p.P545S	Mewo	skin	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0833
p.D572Y	TCGA-AX-A2HC	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556
p.P544S	TCGA-FW-A3R5	SKCM	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556
p.P544S	SIDM00957	Colorectal Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556
p.P544S	SIDM00698	Small Cell Lung Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556
p.P544S	NCI-H146	lung	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556
p.P544S	COLO-678	large_intestine	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_DBOX_1	554:562	QRRPLAVLK	APC,CDC20,FZR1	0.9844	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons