DegronMD

Uniprot ID: Q5T8A7

Source protein: Protein phosphatase 1 regulatory subunit 26

Source gene: PPP1R26

Class: DEG_SPOP_SBC_1

Location: 939:943

E3 ligase: SPOP

DEGRON score: 0.9127

ASA_SCORE: 100.92

COIL: 0.908

CONS_SCORE: 0.4195

DSS_SCORE: 0.6914

HELIX: 0.031

FCONS_SCORE: 1.1695

RIG_SCORE: 0.5937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P931H	TCGA-BF-A1PZ	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1111
p.P931H	DO50279	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.P936L	DO224689	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.25
p.A948T	DO52439	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1944
p.G945C	DO231149	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2778
p.G944S	SIDM00557	Neuroblastoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.G944S	SIDM00075	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.G944S	SIDM00362	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.G944S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.G944S	SIDM01695	Acute Myeloid Leukemia	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P938L	SIDM00845	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P938L	SIDM01147	Gastric Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.D935N	SIDM00806	Osteosarcoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.D935N	HOS	bone	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.G950E	SIDM01520	Oral Cavity Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons