DegronMD

Uniprot ID: Q6ZU52

Source protein: Uncharacterized protein KIAA0408

Source gene: KIAA0408

Class: DEG_SPOP_SBC_1

Location: 270:274

E3 ligase: SPOP

DEGRON score: 0.9827

ASA_SCORE: 85.54

COIL: 0.892

CONS_SCORE: 0.8672

DSS_SCORE: 0.7576

HELIX: 0.0672

FCONS_SCORE: 1.5961

RIG_SCORE: 0.5894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R275Q	TCGA-AG-A002	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	TCGA-EI-6917	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	DO222363	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	DO36881	READ	ICGC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	ACH-000626	Myeloma	CCLE	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.R275Q	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.3056
p.P265S	TCGA-AG-A002	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1944
p.R271I	TCGA-B5-A0JY	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	0.6991
p.R271I	DO43041	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	0.6991
p.S280L	TCGA-EE-A182	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	0.1667
p.S280L	DO37814	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1667
p.E283K	DO234230	ESAD	ICGC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.P266Q	DO229032	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.N262D	DO222415	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	0.1111
p.F277C	DO36556	READ	ICGC	PRSTS	DEG_SPOP_SBC_1	0.25
p.R261K	SIDM00545	Melanoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.R261K	ACH-000987	Skin Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	0.0833
p.R261K	Mewo	skin	COSMIC	PRSTS	DEG_SPOP_SBC_1	0.0833
p.P278S	SIDM00779	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2222
p.P278S	SIDM01188	Pancreatic Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SPOP_SBC_1	1856:1860	PRSTS	SPOP	0.6142	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	428:432	PRSTS	SPOP	0.917	More...
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	DEG_SPOP_SBC_1	3:7	PRSTS	SPOP	0.6647	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	314:318	PRSTS	SPOP	0.9761	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	939:943	PRSTS	SPOP	0.9127	More...
Q6ZU52	Uncharacterized protein KIAA0408	DEG_SPOP_SBC_1	270:274	PRSTS	SPOP	0.9827	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	842:846	PRSTS	SPOP	0.9784	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	798:802	PRSTS	SPOP	0.999	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	873:877	PRSTS	SPOP	0.9983	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	1109:1113	PRSTS	SPOP	0.9954	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	1104:1108	PRSTS	SPOP	0.6375	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	344:348	PRSTS	SPOP	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons