DegronMD - Q6ZU52(KIAA0408)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A416V	TCGA-78-7147	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.5825
p.A416V	DO24527	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.5825
p.C411G	TCGA-AA-3663	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.1944
p.C411G	DO9346	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.1944
p.S414L	TCGA-AC-A23H	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.2778
p.S414L	DO2401	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.2778
p.E417K	TCGA-AG-A002	READ	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.591
p.E417K	DO50799	LIRI	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.591
p.E417K	SIDM00272	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.591
p.E417K	ACH-000910	Breast Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.591
p.E417K	MDA-MB-453	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.591
p.R275Q	TCGA-AG-A002	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	TCGA-EI-6917	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	DO222363	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	DO36881	READ	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	ACH-000626	Myeloma	CCLE	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	U-266	haematopoietic and lymphoid tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.R275Q	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.P265S	TCGA-AG-A002	READ	TCGA	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1944
p.R271I	TCGA-B5-A0JY	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6991
p.R271I	DO43041	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.6991
p.S413F	TCGA-BH-A0HF	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.25
p.S413F	DO1749	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.25
p.S280L	TCGA-EE-A182	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.S280L	DO37814	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.P421Q	TCGA-FS-A1ZQ	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.3056
p.P421Q	DO37442	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.3056
p.E283K	DO234230	ESAD	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.S418R	DO229026	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.7427
p.P266Q	DO229032	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.H406N	DO229045	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.0556
p.N262D	DO222415	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.F277C	DO36556	READ	ICGC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.25
p.R261K	SIDM00545	Melanoma	GDSC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.R261K	ACH-000987	Skin Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.R261K	Mewo	skin	COSMIC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0833
p.H406Q	SIDM00562	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.0556
p.H406Q	ACH-002163	Breast Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.0556
p.H406Q	MRK-nu-1	breast	COSMIC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.0556
p.P278S	SIDM00779	Colorectal Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.P278S	SIDM01188	Pancreatic Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.V415G	SIDM01680	Non-Cancerous	GDSC	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.3056
p.V415G	ACH-002364	Non-Cancerous	CCLE	AESSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0408

UniProt ID: Q6ZU52

Entrez ID: 9729

Protein name: Uncharacterized protein KIAA0408

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0408 in