DegronMD

Uniprot ID: Q9H792

Source protein: Inactive tyrosine-protein kinase PEAK1

Source gene: PEAK1

Class: DEG_SPOP_SBC_1

Location: 534:538

E3 ligase: SPOP

DEGRON score: 0.9834

ASA_SCORE: 91.72

COIL: 0.8654

CONS_SCORE: 0.612

DSS_SCORE: 0.4872

HELIX: 0.0418

FCONS_SCORE: 1.242

RIG_SCORE: 0.7517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K544N	TCGA-A5-A2K5	UCEC	TCGA	VWTSS	DEG_SPOP_SBC_1	0.2778
p.K544N	DO41379	UCEC	ICGC	VWTSS	DEG_SPOP_SBC_1	0.2778
p.E533K	DO224768	BRCA	ICGC	VWTSS	DEG_SPOP_SBC_1	0.3056
p.Q543K	DO228985	LICA	ICGC	VWTSS	DEG_SPOP_SBC_1	0.1944
p.T539N	DO229037	LICA	ICGC	VWTSS	DEG_SPOP_SBC_1	0.75
p.S526Y	DO23539	LIRI	ICGC	VWTSS	DEG_SPOP_SBC_1	0.1111
p.W535R	DO232761	PBCA	ICGC	VWTSS	DEG_SPOP_SBC_1	0.7523
p.S538I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	VWTSS	DEG_SPOP_SBC_1	0.7341
p.S538I	ACH-000869	Lung Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	0.7341
p.S538I	NCI-H1568	lung	COSMIC	VWTSS	DEG_SPOP_SBC_1	0.7341
p.K525N	ACH-000774	Lung Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	0.1944
p.K544T	ACH-002680	Brain Cancer	CCLE	VWTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	534:538	VWTSS	SPOP	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons