DegronMD

Uniprot ID: Q9H792

Source protein: Inactive tyrosine-protein kinase PEAK1

Source gene: PEAK1

Class: LIG_APCC_ABBA_1

Location: 608:613

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9809

ASA_SCORE: 102.75

COIL: 0.9328

CONS_SCORE: 0.57

DSS_SCORE: 0.3455

HELIX: 0.0132

FCONS_SCORE: 0.947

RIG_SCORE: 0.8322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T615A	TCGA-BR-A4J8	STAD	TCGA	IIIHDE	LIG_APCC_ABBA_1	0.7222
p.T615A	DO38527	STAD	ICGC	IIIHDE	LIG_APCC_ABBA_1	0.7222
p.H611Y	DO234344	ESAD	ICGC	IIIHDE	LIG_APCC_ABBA_1	0.6118
p.I608V	DO222824	MELA	ICGC	IIIHDE	LIG_APCC_ABBA_1	0.5965
p.H611Q	SIDM00181	Bladder Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	0.7582
p.H611Q	ACH-002266	Bladder Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	0.7582
p.H611Q	LB831-BLC	urinary_tract	COSMIC	IIIHDE	LIG_APCC_ABBA_1	0.7582
p.N599S	SIDM00537	Colorectal Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	0.0833
p.N599S	ACH-000982	Colon/Colorectal Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	0.0833
p.N599S	ACH-001345	Colon/Colorectal Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	0.0833
p.N599S	GP5d	large_intestine	COSMIC	IIIHDE	LIG_APCC_ABBA_1	0.0833
p.M603L	SIDM00999	Bladder Carcinoma	GDSC	IIIHDE	LIG_APCC_ABBA_1	0.1944
p.M603L	ACH-000973	Bladder Cancer	CCLE	IIIHDE	LIG_APCC_ABBA_1	0.1944
p.M603L	639-V	urinary_tract	COSMIC	IIIHDE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H792	Inactive tyrosine-protein kinase PEAK1	LIG_APCC_ABBA_1	608:613	IIIHDE	APC,CDC20,FZR1	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons