DegronMD

Uniprot ID: Q9H792

Source protein: Inactive tyrosine-protein kinase PEAK1

Source gene: PEAK1

Class: DEG_APCC_KENBOX_2

Location: 1444:1448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6099

ASA_SCORE: 102.3

COIL: 0.5764

CONS_SCORE: 0.2133

DSS_SCORE: 0.6465

HELIX: 0.4032

FCONS_SCORE: 0.8411

RIG_SCORE: 0.6373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1444H	TCGA-DK-AA71	BLCA	TCGA	QKENQ	DEG_APCC_KENBOX_2	0.647
p.Q1444H	DO219010	BLCA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.647
p.S1443F	TCGA-IB-7651	PAAD	TCGA	QKENQ	DEG_APCC_KENBOX_2	0.3056
p.S1443F	DO46657	PAAD	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.3056
p.E1439K	TCGA-VS-A9U7	CESC	TCGA	QKENQ	DEG_APCC_KENBOX_2	0.1944
p.E1439K	DO219729	CESC	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.1944
p.A1440V	DO233900	GACA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.2222
p.A1440E	DO229037	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.2222
p.Q1448K	DO229045	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_APCC_KENBOX_2	1444:1448	QKENQ	APC,CDC20,FZR1	0.6099	More...
Q9P2G4	Microtubule-associated protein 10	DEG_APCC_KENBOX_2	807:811	QKENQ	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons