DegronMD

Uniprot ID: Q9P2G4

Source protein: Microtubule-associated protein 10

Source gene: MAP10

Class: DEG_APCC_KENBOX_2

Location: 807:811

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 121.68

COIL: 0.707

CONS_SCORE: 0.5861

DSS_SCORE: 0.6177

HELIX: 0.2616

FCONS_SCORE: 1.2418

RIG_SCORE: 0.7083

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D815Y	TCGA-19-5956	GBM	TCGA	QKENQ	DEG_APCC_KENBOX_2	0.2222
p.D815Y	DO13863	GBM	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.2222
p.E805D	TCGA-ZF-AA4V	BLCA	TCGA	QKENQ	DEG_APCC_KENBOX_2	0.2778
p.E805D	DO219087	BLCA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.2778
p.V798F	DO229038	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.0833
p.T814I	DO50755	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	0.25
p.D817G	SIDM00194	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00614	Hepatocellular Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01040	Ovarian Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00535	Chondrosarcoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00607	Glioblastoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01005	Acute Myeloid Leukemia	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01144	Gastric Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00282	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00054	Pancreatic Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00217	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01439	Hepatocellular Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00169	Head and Neck Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM00166	Other Solid Cancers	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01776	Plasma Cell Myeloma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01454	Kidney Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.D817G	SIDM01559	Melanoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1667
p.V802L	SIDM00120	Prostate Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.1944
p.V802L	ACH-000979	Prostate Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	0.1944
p.V802L	DU-145	prostate	COSMIC	QKENQ	DEG_APCC_KENBOX_2	0.1944
p.R809G	SIDM01138	Pancreatic Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	0.7568
p.R809G	ACH-000139	Pancreatic Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	0.7568
p.R809G	PANC-03-27	pancreas	COSMIC	QKENQ	DEG_APCC_KENBOX_2	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_APCC_KENBOX_2	1444:1448	QKENQ	APC,CDC20,FZR1	0.6099	More...
Q9P2G4	Microtubule-associated protein 10	DEG_APCC_KENBOX_2	807:811	QKENQ	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENQ

Degron related mutations and impact score

Drug responses associated with MAP10 mutations

All proteins holding degron of QKENQ