DegronMD - Q9P2G4(MAP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D815Y	TCGA-19-5956	GBM	TCGA	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2222
p.D815Y	DO13863	GBM	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2222
p.R303C	TCGA-AX-A1CE	UCEC	TCGA	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	TCGA-FI-A2D0	UCEC	TCGA	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	DO42280	UCEC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	DO43891	UCEC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R309Q	TCGA-CA-6717	COAD	TCGA	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.R309Q	DO8264	COAD	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.R309Q	DO233703	GACA	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.T314A	TCGA-CR-7373	HNSC	TCGA	PPLY	ITCH	302:305	Mutation rewiring degron network	0.0833
p.T314A	DO16093	HNSC	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.0833
p.G315V	TCGA-EJ-7125	PRAD	TCGA	PPLY	ITCH	302:305	Mutation rewiring degron network	0.0556
p.G315V	DO36326	PRAD	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.0556
p.E312K	TCGA-OL-A5RW	BRCA	TCGA	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.E312K	DO44238	BRCA	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.E805D	TCGA-ZF-AA4V	BLCA	TCGA	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.E805D	DO219087	BLCA	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.V798F	DO229038	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.0833
p.T814I	DO50755	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.25
p.R303L	DO230538	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.R303L	DO231022	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.R303L	DO231106	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.D817G	SIDM00194	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00614	Hepatocellular Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01040	Ovarian Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00535	Chondrosarcoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00607	Glioblastoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01005	Acute Myeloid Leukemia	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01144	Gastric Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00282	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00054	Pancreatic Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00217	Colorectal Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01439	Hepatocellular Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00169	Head and Neck Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM00166	Other Solid Cancers	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01776	Plasma Cell Myeloma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01454	Kidney Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.D817G	SIDM01559	Melanoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1667
p.G295R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM00967	Ovarian Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM00879	Breast Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM00806	Osteosarcoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM00493	Other Solid Cancers	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM00807	Bladder Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM01409	Bladder Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.G295R	SIDM01525	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1389
p.V802L	SIDM00120	Prostate Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944
p.V802L	ACH-000979	Prostate Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944
p.V802L	DU-145	prostate	COSMIC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944
p.C296W	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1667
p.C296W	EC-GI-10	oesophagus	COSMIC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.1667
p.R809G	SIDM01138	Pancreatic Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568
p.R809G	ACH-000139	Pancreatic Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568
p.R809G	PANC-03-27	pancreas	COSMIC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP10

UniProt ID: Q9P2G4

Entrez ID: 54627

Protein name: Microtubule-associated protein 10 (Microtubule regulator of 120 KDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP10 in