DegronMD - Q9P2G4(MAP10)

FUNCTION: Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. {ECO:0000269|PubMed:23264731}.

GO - Biological processes (BP): cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886]

GO - Molecular function (MF): microtubule binding [GO:0008017]

GO - Cellular component (CC): centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R303L	DO230538	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.R303L	DO231022	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.R303L	DO231106	LUSC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8428
p.R303C	TCGA-AX-A1CE	UCEC	TCGA	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	TCGA-FI-A2D0	UCEC	TCGA	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	DO42280	UCEC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R303C	DO43891	UCEC	ICGC	PPLY	ITCH	302:305	Mutation altering degron motif	0.8301
p.R809G	SIDM01138	Pancreatic Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568
p.R809G	ACH-000139	Pancreatic Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568
p.R809G	PANC-03-27	pancreas	COSMIC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation altering degron motif	0.7568
p.E805D	TCGA-ZF-AA4V	BLCA	TCGA	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.E805D	DO219087	BLCA	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2778
p.T814I	DO50755	LICA	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.25
p.D815Y	TCGA-19-5956	GBM	TCGA	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2222
p.D815Y	DO13863	GBM	ICGC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.2222
p.R309Q	TCGA-CA-6717	COAD	TCGA	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.R309Q	DO8264	COAD	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.R309Q	DO233703	GACA	ICGC	PPLY	ITCH	302:305	Mutation rewiring degron network	0.2222
p.V802L	SIDM00120	Prostate Carcinoma	GDSC	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944
p.V802L	ACH-000979	Prostate Cancer	CCLE	QKENQ	DEG_APCC_KENBOX_2	807:811	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 56 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP10

UniProt ID: Q9P2G4

Entrez ID: 54627

Protein name: Microtubule-associated protein 10 (Microtubule regulator of 120 KDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP10 in