DegronMD

Uniprot ID: P13646

Source protein: Keratin, type I cytoskeletal 13

Source gene: KRT13

Class: DEG_SPOP_SBC_1

Location: 441:445

E3 ligase: SPOP

DEGRON score: 0.8837

ASA_SCORE: 71.58

COIL: 0.3558

CONS_SCORE: 0.8544

DSS_SCORE: 0.6104

HELIX: 0.0298

FCONS_SCORE: 0.9854

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R451H	TCGA-AX-A1CE	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1667
p.R451H	DO234401	ESAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1667
p.R451H	DO42280	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1667
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.3056
p.T452N	DO229031	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.5833
p.A439D	DO229045	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.R450C	SIDM01958	Esophageal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons