DegronMD

Uniprot ID: Q6ZU65

Source protein: Ubinuclein-2

Source gene: UBN2

Class: DEG_SPOP_SBC_1

Location: 1283:1287

E3 ligase: SPOP

DEGRON score: 0.5985

ASA_SCORE: 83.46

COIL: 0.8834

CONS_SCORE: 0.3163

DSS_SCORE: 0.3654

HELIX: 0.0182

FCONS_SCORE: 0.9955

RIG_SCORE: 0.7386

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1290I	TCGA-06-5408	GBM	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.T1290I	DO12862	GBM	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.T1285I	TCGA-66-2791	LUSC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7078
p.T1285I	DO26435	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7078
p.S1287L	TCGA-UY-A9PB	BLCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7667
p.S1287L	DO219041	BLCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7667
p.S1287L	ACH-001513	Cervical Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.7667
p.F1274C	DO222798	COCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.T1278M	DO229259	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.I1273L	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	ACH-000786	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	ACH-000992	Head and Neck Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	ACH-001067	Brain Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.I1273L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.F1274L	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.F1274L	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.F1274L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.F1274L	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.F1274L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.F1274L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.T1285A	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.7139
p.T1285A	SIDM01519	Head and Neck Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.7139
p.T1285A	ACH-000786	Lymphoma	CCLE	VTTTS	DEG_SPOP_SBC_1	0.7139
p.T1285A	ACH-000992	Head and Neck Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.7139
p.T1285A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTTS

Degron related mutations and impact score

Drug responses associated with UBN2 mutations

All proteins holding degron of VTTTS