DegronMD

Uniprot ID: Q9NYZ4

Source protein: Sialic acid-binding Ig-like lectin 8

Source gene: SIGLEC8

Class: DEG_SPOP_SBC_1

Location: 233:237

E3 ligase: SPOP

DEGRON score: 0.8068

ASA_SCORE: 66.06

COIL: 0.2544

CONS_SCORE: 0.335

DSS_SCORE: 0.3514

HELIX: 0.004

FCONS_SCORE: 0.5815

RIG_SCORE: 0.801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R240L	TCGA-05-4424	LUAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.R240L	DO23672	LUAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.P247A	TCGA-28-5207	GBM	TCGA	VTTTS	DEG_SPOP_SBC_1	0.0556
p.L228F	TCGA-44-6145	LUAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1944
p.L228F	DO25123	LUAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	TCGA-AN-A046	BRCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	TCGA-FI-A2D5	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	DO1285	BRCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	DO52365	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	DO41331	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	SIDM00267	Biliary Tract Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	ACH-002312	Gallbladder Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242N	TGBC24TKB	biliary_tract	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.R240H	TCGA-AN-A0AM	BRCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.R240H	TCGA-XM-AAZ1	THYM	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.R240H	DO4191	BRCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.R240H	DO35600	PBCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.R240H	SIDM02068	Esophageal Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.25
p.D242G	TCGA-AP-A056	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1944
p.D242G	DO43971	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1944
p.P246L	TCGA-AP-A1DV	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.0833
p.P246S	TCGA-EE-A2M5	SKCM	TCGA	VTTTS	DEG_SPOP_SBC_1	0.0833
p.T236I	TCGA-EO-A22U	UCEC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7078
p.T236I	TCGA-VQ-A91K	STAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7078
p.T236I	DO51785	STAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7078
p.T236I	DO43755	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7078
p.T235M	TCGA-G4-6323	COAD	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7423
p.T235M	DO9138	COAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7423
p.Q225K	DO223588	BLCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1111
p.A224T	DO9666	COAD	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.G230R	DO222469	ESCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.S237N	DO233154	GACA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7069
p.S237N	DO23509	LIRI	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7069
p.G232C	DO233766	GACA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.3056
p.S244T	DO26890	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1389
p.L236M	DO26710	LUSC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.711
p.S231F	DO222843	MELA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.S231F	DO51272	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.S231F	DO51269	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.G240D	DO38123	SKCM	ICGC	VTTTS	DEG_SPOP_SBC_1	0.25
p.S237G	DO229208	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.6993
p.A224V	DO42472	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.N238I	DO41379	UCEC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.3056
p.V239I	SIDM00578	Neuroblastoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.V239I	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.V239I	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.L241I	SIDM00094	Kidney Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.2222
p.L241I	ACH-002199	Kidney Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.2222
p.L241I	SN12C	kidney	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.2222
p.T223N	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.T223N	ACH-000826	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0556
p.T223N	CAL-12T	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.P246H	ACH-000901	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.0833
p.R224Q	U-87-MG	central_nervous_system	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.0833
p.E239D	NCI-H2347	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.R228M	NCI-H748	lung	COSMIC	VTTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTTS

Degron related mutations and impact score

Drug responses associated with SIGLEC8 mutations

All proteins holding degron of VTTTS