DegronMD

Uniprot ID: P13646

Source protein: Keratin, type I cytoskeletal 13

Source gene: KRT13

Class: DEG_SPOP_SBC_1

Location: 433:437

E3 ligase: SPOP

DEGRON score: 0.9542

ASA_SCORE: 89.72

COIL: 0.7834

CONS_SCORE: 0.8737

DSS_SCORE: 0.5607

HELIX: 0.0232

FCONS_SCORE: 1.0279

RIG_SCORE: 0.6538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T435M	TCGA-AB-2826	LAML	TCGA	VTTTS	DEG_SPOP_SBC_1	0.7423
p.T435M	DO21833	LAML	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7423
p.S440F	TCGA-IG-A5S3	ESCA	TCGA	VTTTS	DEG_SPOP_SBC_1	0.25
p.A423T	DO229036	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.0556
p.A439D	DO229045	LICA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.S425N	DO232224	PBCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.5556
p.V426I	SIDM01261	Breast Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1389
p.V426I	SIDM00868	Non-Cancerous	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1389
p.V426I	SIDM01049	Non-Cancerous	GDSC	VTTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons