DegronMD

Uniprot ID: Q96FS4

Source protein: Signal-induced proliferation-associated protein 1

Source gene: SIPA1

Class: DEG_SPOP_SBC_1

Location: 544:548

E3 ligase: SPOP

DEGRON score: 0.9169

ASA_SCORE: 69.44

COIL: 0.7504

CONS_SCORE: 0.3061

DSS_SCORE: 0.4368

HELIX: 0.1884

FCONS_SCORE: 0.779

RIG_SCORE: 0.7829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L536Q	TCGA-DD-AAD1	LIHC	TCGA	VTTTS	DEG_SPOP_SBC_1	0.1111
p.L536Q	DO52218	LIHC	ICGC	VTTTS	DEG_SPOP_SBC_1	0.1111
p.T547K	DO229208	THCA	ICGC	VTTTS	DEG_SPOP_SBC_1	0.7306
p.N542K	SIDM00965	Small Cell Lung Carcinoma	GDSC	VTTTS	DEG_SPOP_SBC_1	0.2778
p.N542K	ACH-000800	Lung Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.2778
p.T547A	ACH-000940	Endometrial/Uterine Cancer	CCLE	VTTTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	433:437	VTTTS	SPOP	0.9542	More...
P13646	Keratin, type I cytoskeletal 13	DEG_SPOP_SBC_1	441:445	VTTTS	SPOP	0.8837	More...
P31629	Transcription factor HIVEP2	DEG_SPOP_SBC_1	440:444	VTTTS	SPOP	0.9813	More...
Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	DEG_SPOP_SBC_1	484:488	VTTTS	SPOP	0.5226	More...
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SPOP_SBC_1	544:548	VTTTS	SPOP	0.9169	More...
Q9NYZ4	Sialic acid-binding Ig-like lectin 8	DEG_SPOP_SBC_1	233:237	VTTTS	SPOP	0.8068	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1283:1287	VTTTS	SPOP	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons