DegronMD

Uniprot ID: Q5T200

Source protein: Zinc finger CCCH domain-containing protein 13

Source gene: ZC3H13

Class: DEG_SCF_FBW7_1

Location: 1168:1174

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 104.9

COIL: 0.9383

CONS_SCORE: 0.3196

DSS_SCORE: 0.6461

HELIX: 0.0394

FCONS_SCORE: 0.9553

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1158K	TCGA-AP-A0LM	UCEC	TCGA	VETPHVT	DEG_SCF_FBW7_1	0.0556
p.R1158K	DO43306	UCEC	ICGC	VETPHVT	DEG_SCF_FBW7_1	0.0556
p.P1183T	DO229028	LICA	ICGC	VETPHVT	DEG_SCF_FBW7_1	0.0833
p.V1173M	DO36556	READ	ICGC	VETPHVT	DEG_SCF_FBW7_1	0.6097
p.R1181H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VETPHVT	DEG_SCF_FBW7_1	0.1389
p.H1172D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	VETPHVT	DEG_SCF_FBW7_1	0.6577
p.H1172D	ACH-000893	Lung Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	0.6577
p.H1172D	NCI-H1651	lung	COSMIC	VETPHVT	DEG_SCF_FBW7_1	0.6577
p.E1166Q	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VETPHVT	DEG_SCF_FBW7_1	0.2778
p.E1166Q	ACH-000945	Lung Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	0.2778
p.E1166Q	NCI-H650	lung	COSMIC	VETPHVT	DEG_SCF_FBW7_1	0.2778
p.R1158T	ACH-001955	Bone Cancer	CCLE	VETPHVT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SCF_FBW7_1	1168:1174	VETPHVT	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons