DegronMD

Uniprot ID: Q5JSZ5

Source protein: Protein PRRC2B

Source gene: PRRC2B

Class: DEG_SCF_FBW7_1

Location: 735:740

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 99.8

COIL: 0.9813

CONS_SCORE: 0.8148

DSS_SCORE: 0.5497

HELIX: 0.008

FCONS_SCORE: 0.8763

RIG_SCORE: 0.7075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P742H	TCGA-G4-6588	COAD	TCGA	VTPIDS	DEG_SCF_FBW7_1	0.2778
p.P742H	DO10140	COAD	ICGC	VTPIDS	DEG_SCF_FBW7_1	0.2778
p.P742H	SIDM01951	Colorectal Carcinoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	0.2778
p.C726R	TCGA-LC-A66R	BLCA	TCGA	VTPIDS	DEG_SCF_FBW7_1	0.0833
p.C726R	DO44031	BLCA	ICGC	VTPIDS	DEG_SCF_FBW7_1	0.0833
p.I738F	TCGA-NC-A5HP	LUSC	TCGA	VTPIDS	DEG_SCF_FBW7_1	0.6304
p.I738F	DO219199	LUSC	ICGC	VTPIDS	DEG_SCF_FBW7_1	0.6304
p.R733T	TCGA-Q1-A73O	CESC	TCGA	VTPIDS	DEG_SCF_FBW7_1	0.2778
p.R733T	DO51612	CESC	ICGC	VTPIDS	DEG_SCF_FBW7_1	0.2778
p.P729S	DO229341	BTCA	ICGC	VTPIDS	DEG_SCF_FBW7_1	0.1667
p.W744R	SIDM00258	Neuroblastoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	0.2222
p.W744R	SIDM00564	Ovarian Carcinoma	GDSC	VTPIDS	DEG_SCF_FBW7_1	0.2222
p.P737S	SIDM00853	Other Sarcomas	GDSC	VTPIDS	DEG_SCF_FBW7_1	0.6752
p.P737S	ACH-000835	Sarcoma	CCLE	VTPIDS	DEG_SCF_FBW7_1	0.6752
p.P737S	GCT	soft_tissue	COSMIC	VTPIDS	DEG_SCF_FBW7_1	0.6752
p.R733I	ACH-000306	Non-Cancerous	CCLE	VTPIDS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSZ5	Protein PRRC2B	DEG_SCF_FBW7_1	735:740	VTPIDS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons