DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: LIG_APCC_ABBA_1

Location: 1635:1640

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9151

ASA_SCORE: 86.5667

COIL: 0.8275

CONS_SCORE: 0.5819

DSS_SCORE: 0.5662

HELIX: 0.1443

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1637L	TCGA-DA-A1IC	SKCM	TCGA	LSPFED	LIG_APCC_ABBA_1	0.6471
p.P1637L	TCGA-QB-A6FS	SKCM	TCGA	LSPFED	LIG_APCC_ABBA_1	0.6471
p.P1637L	DO37430	SKCM	ICGC	LSPFED	LIG_APCC_ABBA_1	0.6471
p.P1637L	DO48654	SKCM	ICGC	LSPFED	LIG_APCC_ABBA_1	0.6471
p.E1645Q	TCGA-GV-A3JX	BLCA	TCGA	LSPFED	LIG_APCC_ABBA_1	0.1944
p.E1645Q	DO448	BLCA	ICGC	LSPFED	LIG_APCC_ABBA_1	0.1944
p.M1632V	DO220896	MELA	ICGC	LSPFED	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	LIG_APCC_ABBA_1	1635:1640	LSPFED	APC,CDC20,FZR1	0.9151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons