DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: LIG_APCC_ABBA_1

Location: 2055:2060

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9424

ASA_SCORE: 93.4833

COIL: 0.788

CONS_SCORE: 0.646

DSS_SCORE: 0.5022

HELIX: 0.181

FCONS_SCORE: 1.111

RIG_SCORE: 0.7659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2045F	TCGA-CN-6010	HNSC	TCGA	LKPFQD	LIG_APCC_ABBA_1	0.0556
p.L2045F	DO14766	HNSC	ICGC	LKPFQD	LIG_APCC_ABBA_1	0.0556
p.S2066I	TCGA-DX-A8BG	SARC	TCGA	LKPFQD	LIG_APCC_ABBA_1	0.1667
p.S2066I	DO220042	SARC	ICGC	LKPFQD	LIG_APCC_ABBA_1	0.1667
p.P2057L	TCGA-G4-6302	COAD	TCGA	LKPFQD	LIG_APCC_ABBA_1	0.6471
p.P2057L	DO8778	COAD	ICGC	LKPFQD	LIG_APCC_ABBA_1	0.6471
p.P2057L	DO50733	ORCA	ICGC	LKPFQD	LIG_APCC_ABBA_1	0.6471
p.P2057L	SIDM02021	Esophageal Carcinoma	GDSC	LKPFQD	LIG_APCC_ABBA_1	0.6471
p.F2058L	DO225192	BRCA	ICGC	LKPFQD	LIG_APCC_ABBA_1	0.6981
p.L2055P	SIDM00185	Melanoma	GDSC	LKPFQD	LIG_APCC_ABBA_1	0.7582
p.L2055P	ACH-002152	Skin Cancer	CCLE	LKPFQD	LIG_APCC_ABBA_1	0.7582
p.L2055P	LB2518-MEL	skin	COSMIC	LKPFQD	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	LIG_APCC_ABBA_1	2055:2060	LKPFQD	APC,CDC20,FZR1	0.9424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons