DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_SCF_FBW7_2

Location: 540:545

E3 ligase: FBXW7

DEGRON score: 0.957

ASA_SCORE: 106.55

COIL: 0.9553

CONS_SCORE: 0.4199

DSS_SCORE: 0.8842

HELIX: 0.0272

FCONS_SCORE: 0.8668

RIG_SCORE: 0.5082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A539V	TCGA-BQ-7044	KIRP	TCGA	PTPETE	DEG_SCF_FBW7_2	0.3056
p.A539V	DO20942	KIRP	ICGC	PTPETE	DEG_SCF_FBW7_2	0.3056
p.A550T	TCGA-DU-6392	LGG	TCGA	PTPETE	DEG_SCF_FBW7_2	0.1944
p.A550T	DO22237	LGG	ICGC	PTPETE	DEG_SCF_FBW7_2	0.1944
p.P554S	DO220911	MELA	ICGC	PTPETE	DEG_SCF_FBW7_2	0.0833
p.P554L	SIDM00007	Other Solid Cancers	GDSC	PTPETE	DEG_SCF_FBW7_2	0.0833
p.P554L	ACH-001550	Skin Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	0.0833
p.P554L	MCC13	skin	COSMIC	PTPETE	DEG_SCF_FBW7_2	0.0833
p.P535A	SIDM00498	Colorectal Carcinoma	GDSC	PTPETE	DEG_SCF_FBW7_2	0.1944
p.P535A	ACH-000970	Colon/Colorectal Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	0.1944
p.P535A	SNU-C5	large_intestine	COSMIC	PTPETE	DEG_SCF_FBW7_2	0.1944
p.E547K	SIDM00920	Breast Carcinoma	GDSC	PTPETE	DEG_SCF_FBW7_2	0.2778
p.E547K	ACH-000783	Breast Cancer	CCLE	PTPETE	DEG_SCF_FBW7_2	0.2778
p.E547K	CAMA-1	breast	COSMIC	PTPETE	DEG_SCF_FBW7_2	0.2778
p.T541I	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPETE	DEG_SCF_FBW7_2	0.7078
p.T541I	ACH-002222	Leukemia	CCLE	PTPETE	DEG_SCF_FBW7_2	0.7078
p.T541I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPETE	DEG_SCF_FBW7_2	0.7078
p.A539T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PTPETE	DEG_SCF_FBW7_2	0.3056
p.A539T	ACH-000937	Leukemia	CCLE	PTPETE	DEG_SCF_FBW7_2	0.3056
p.A539T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PTPETE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_SCF_FBW7_2	540:545	PTPETE	FBXW7	0.957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons