DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_COP1_1

Location: 130:139

E3 ligase: COP1

DEGRON score: 0.9428

ASA_SCORE: 90.63

COIL: 0.9416

CONS_SCORE: 0.6621

DSS_SCORE: 0.655

HELIX: 0.0255

FCONS_SCORE: 0.9066

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G138R	TCGA-13-1498	OV	TCGA	ENTPLVPSGV	DEG_COP1_1	0.7568
p.G138R	DO30180	OV	ICGC	ENTPLVPSGV	DEG_COP1_1	0.7568
p.P122L	TCGA-32-2616	GBM	TCGA	ENTPLVPSGV	DEG_COP1_1	0.1111
p.P122L	DO13462	GBM	ICGC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	TCGA-AX-A3G9	UCEC	TCGA	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	DO41241	UCEC	ICGC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	SIDM00215	Colorectal Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	SIDM00489	Oral Cavity Carcinoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	SIDM00324	Neuroblastoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	TGW	autonomic_ganglia	COSMIC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	KYSE-220	oesophagus	COSMIC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	Ca9-22	upper_aerodigestive_tract	COSMIC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V147I	SNU-283	large_intestine	COSMIC	ENTPLVPSGV	DEG_COP1_1	0.1111
p.V139I	DO233747	GACA	ICGC	ENTPLVPSGV	DEG_COP1_1	0.5965
p.P136S	DO228326	MALY	ICGC	ENTPLVPSGV	DEG_COP1_1	0.6752
p.A127T	SIDM00845	Burkitt's Lymphoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.25
p.A127T	ACH-000786	Lymphoma	CCLE	ENTPLVPSGV	DEG_COP1_1	0.25
p.A127T	ACH-001067	Brain Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	0.25
p.L134S	SIDM00845	Burkitt's Lymphoma	GDSC	ENTPLVPSGV	DEG_COP1_1	0.6556
p.S146N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ENTPLVPSGV	DEG_COP1_1	0.5833
p.S146N	ACH-001737	Leukemia	CCLE	ENTPLVPSGV	DEG_COP1_1	0.5833
p.S146N	ACH-002222	Leukemia	CCLE	ENTPLVPSGV	DEG_COP1_1	0.5833
p.S146N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ENTPLVPSGV	DEG_COP1_1	0.5833
p.Q144K	ACH-000679	Esophageal Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	0.1944
p.P133L	ACH-001551	Skin Cancer	CCLE	ENTPLVPSGV	DEG_COP1_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_COP1_1	130:139	ENTPLVPSGV	COP1	0.9428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ENTPLVPSGV

Degron related mutations and impact score

Drug responses associated with PRRC2A mutations

All proteins holding degron of ENTPLVPSGV