DegronMD

Uniprot ID: P48634

Source protein: Protein PRRC2A

Source gene: PRRC2A

Class: DEG_COP1_1

Location: 1817:1825

E3 ligase: COP1

DEGRON score: 0.9888

ASA_SCORE: 89.2667

COIL: 0.9532

CONS_SCORE: 0.4174

DSS_SCORE: 0.6332

HELIX: 0.0272

FCONS_SCORE: 0.9289

RIG_SCORE: 0.631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1814T	TCGA-17-Z015	LUAD	TCGA	DSGHCVPEP	DEG_COP1_1	0.6944
p.S1808F	TCGA-18-3409	LUSC	TCGA	DSGHCVPEP	DEG_COP1_1	0.0833
p.S1808F	DO26444	LUSC	ICGC	DSGHCVPEP	DEG_COP1_1	0.0833
p.S1808F	SIDM00864	Cervical Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	0.0833
p.P1823Q	TCGA-BR-4201	STAD	TCGA	DSGHCVPEP	DEG_COP1_1	0.7035
p.P1823Q	DO38707	STAD	ICGC	DSGHCVPEP	DEG_COP1_1	0.7035
p.P1823S	TCGA-QC-A7B5	SARC	TCGA	DSGHCVPEP	DEG_COP1_1	0.6752
p.P1823S	DO220239	SARC	ICGC	DSGHCVPEP	DEG_COP1_1	0.6752
p.P1823L	TCGA-QC-A7B5	SARC	TCGA	DSGHCVPEP	DEG_COP1_1	0.7582
p.P1823L	DO220239	SARC	ICGC	DSGHCVPEP	DEG_COP1_1	0.7582
p.P1823L	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGHCVPEP	DEG_COP1_1	0.7582
p.P1823L	SIDM00616	Hepatocellular Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	0.7582
p.P1823L	SIDM00166	Other Solid Cancers	GDSC	DSGHCVPEP	DEG_COP1_1	0.7582
p.L1832M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGHCVPEP	DEG_COP1_1	0.1389
p.L1832M	ACH-000981	Leukemia	CCLE	DSGHCVPEP	DEG_COP1_1	0.1389
p.L1832M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHCVPEP	DEG_COP1_1	0.1389
p.R1831H	SIDM00781	Colorectal Carcinoma	GDSC	DSGHCVPEP	DEG_COP1_1	0.1667
p.R1831H	ACH-001199	Colon/Colorectal Cancer	CCLE	DSGHCVPEP	DEG_COP1_1	0.1667
p.R1831H	SNU-C2B	large_intestine	COSMIC	DSGHCVPEP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48634	Protein PRRC2A	DEG_COP1_1	1817:1825	DSGHCVPEP	COP1	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons