DegronMD - P56693(SOX10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I378T	TCGA-34-8455	LUSC	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.0833
p.I378T	DO50095	LUSC	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.0833
p.A361V	TCGA-A5-A0G2	UCEC	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.A361V	TCGA-AX-A0J1	UCEC	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.A361V	DO41235	UCEC	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.A361V	DO41199	UCEC	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.T360A	TCGA-CG-4442	STAD	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1667
p.T360A	DO38380	STAD	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1667
p.G233S	TCGA-EB-A430	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1944
p.G233S	TCGA-EB-A430	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.1111
p.G233S	DO37906	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1944
p.G233S	DO37906	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.1111
p.S251L	TCGA-EE-A3AG	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1389
p.S251L	TCGA-EE-A3AG	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.25
p.S251L	DO37471	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1389
p.S251L	DO37471	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.25
p.Q250H	TCGA-EE-A3AG	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1667
p.Q250H	TCGA-EE-A3AG	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.2778
p.Q250H	DO37471	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1667
p.Q250H	DO37471	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.2778
p.A361T	TCGA-HU-A4GU	STAD	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.A361T	DO47849	STAD	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.1944
p.A379T	TCGA-QG-A5YV	COAD	TCGA	PPHY	ITCH	366:369	Mutation rewiring degron network	0.0556
p.A379T	DO44088	COAD	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.0556
p.P238Q	DO48442	BLCA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation altering degron motif	0.7035
p.P245A	DO224920	BRCA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation altering degron motif	0.7503
p.R258Q	DO234170	ESAD	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.0556
p.T247K	DO228986	LICA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation altering degron motif	0.6195
p.H230N	DO229022	LICA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.1111
p.P373T	DO229041	LICA	ICGC	PPHY	ITCH	366:369	Mutation rewiring degron network	0.2222
p.G237D	SIDM01619	Endometrial Carcinoma	GDSC	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.3056
p.G237D	SIDM01619	Endometrial Carcinoma	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.2222
p.G237D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	238:244	Mutation rewiring degron network	0.3056
p.G237D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPTTPKTE	DEG_SCF_FBW7_2	241:248	Mutation rewiring degron network	0.2222

Kaplan plot for SOX10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX10

UniProt ID: P56693

Entrez ID: 6663

Protein name: Transcription factor SOX-10

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX10 in