DegronMD

Uniprot ID: P56693

Source protein: Transcription factor SOX-10

Source gene: SOX10

Class: DEG_SCF_FBW7_2

Location: 241:248

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 86.5375

COIL: 0.9404

CONS_SCORE: 0.4506

DSS_SCORE: 0.9191

HELIX: 0.0316

FCONS_SCORE: 1.1732

RIG_SCORE: 0.5569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G233S	TCGA-EB-A430	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	0.1111
p.G233S	DO37906	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.1111
p.S251L	TCGA-EE-A3AG	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	0.25
p.S251L	DO37471	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.25
p.Q250H	TCGA-EE-A3AG	SKCM	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	0.2778
p.Q250H	DO37471	SKCM	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.2778
p.P245A	DO224920	BRCA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.7503
p.R258Q	DO234170	ESAD	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.0556
p.T247K	DO228986	LICA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.6195
p.G237D	SIDM01619	Endometrial Carcinoma	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	0.2222
p.G237D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPTTPKTE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons