DegronMD - P57073(SOX8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G215D	TCGA-AX-A2HA	UCEC	TCGA	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0833
p.G215D	TCGA-FI-A2D5	UCEC	TCGA	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0833
p.G215D	DO50970	LICA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0833
p.G215D	DO42504	UCEC	ICGC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0833
p.G215D	DO41331	UCEC	ICGC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0833
p.T233M	TCGA-EA-A6QX	CESC	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.6312
p.T233M	DO48997	CESC	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.6312
p.T226S	TCGA-MN-A4N5	LUAD	TCGA	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.8227
p.T226S	DO45332	LUAD	ICGC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.8227
p.P227L	TCGA-ZF-AA4U	BLCA	TCGA	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.7582
p.P227L	TCGA-ZF-AA4U	BLCA	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.6471
p.P227L	DO219085	BLCA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.7582
p.P227L	DO219085	BLCA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.6471
p.P227L	ACH-001443	Thyroid Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.7582
p.P227L	ACH-001443	Thyroid Cancer	CCLE	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.6471
p.K241E	DO42673	UCEC	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation substituting flanking lysine	0.25
p.P242L	SIDM00882	Breast Carcinoma	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.1111
p.P242L	HCC1419	breast	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.1111
p.G223R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.3056
p.G223R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.2222
p.G223R	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.3056
p.G223R	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.2222
p.A240T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0556
p.A240T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.1667
p.A240T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation rewiring degron network	0.0556
p.A240T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation rewiring degron network	0.1667
p.T230A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	224:230	Mutation altering degron motif	0.7139
p.T230A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	227:234	Mutation altering degron motif	0.7139

Kaplan plot for SOX8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX8

UniProt ID: P57073

Entrez ID: 30812

Protein name: Transcription factor SOX-8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX8 in