DegronMD

Uniprot ID: P57073

Source protein: Transcription factor SOX-8

Source gene: SOX8

Class: DEG_SCF_FBW7_1

Location: 224:230

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 85.4

COIL: 0.9773

CONS_SCORE: 0.5169

DSS_SCORE: 0.9238

HELIX: 0.0094

FCONS_SCORE: 1.7061

RIG_SCORE: 0.5239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G215D	TCGA-AX-A2HA	UCEC	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.0833
p.G215D	TCGA-FI-A2D5	UCEC	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.0833
p.G215D	DO50970	LICA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.0833
p.G215D	DO42504	UCEC	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.0833
p.G215D	DO41331	UCEC	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.0833
p.T226S	TCGA-MN-A4N5	LUAD	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.8227
p.T226S	DO45332	LUAD	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.8227
p.P227L	TCGA-ZF-AA4U	BLCA	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.7582
p.P227L	DO219085	BLCA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.7582
p.P227L	ACH-001443	Thyroid Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	0.7582
p.G223R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	0.3056
p.G223R	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	0.3056
p.A240T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	0.0556
p.A240T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	0.0556
p.T230A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTPPTT	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons