DegronMD

Uniprot ID: P48436

Source protein: Transcription factor SOX-9

Source gene: SOX9

Class: DEG_SCF_FBW7_1

Location: 234:240

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 79.3

COIL: 0.9744

CONS_SCORE: 0.4413

DSS_SCORE: 0.9313

HELIX: 0.0094

FCONS_SCORE: 1.2144

RIG_SCORE: 0.4713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235A	TCGA-B0-5109	KIRC	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.6392
p.P235A	DO18769	KIRC	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.6392
p.G248S	DO11854	GBM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1111
p.G248V	DO228985	LICA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1111
p.K249N	SIDM00151	Ovarian Carcinoma	GDSC	PPTPPTT	DEG_SCF_FBW7_1	0.5278
p.K249N	ACH-000966	Ovarian Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	0.5278
p.K249N	IGROV-1	ovary	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	0.5278
p.Q246P	ACH-002118	Bone Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	0.1667
p.Q246P	EW-3	bone	COSMIC	PPTPPTT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons