DegronMD

Uniprot ID: P56693

Source protein: Transcription factor SOX-10

Source gene: SOX10

Class: DEG_SCF_FBW7_1

Location: 238:244

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 70.7429

COIL: 0.9674

CONS_SCORE: 0.4686

DSS_SCORE: 0.9353

HELIX: 0.0119

FCONS_SCORE: 1.1793

RIG_SCORE: 0.4692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G233S	TCGA-EB-A430	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.1944
p.G233S	DO37906	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1944
p.S251L	TCGA-EE-A3AG	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.1389
p.S251L	DO37471	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1389
p.Q250H	TCGA-EE-A3AG	SKCM	TCGA	PPTPPTT	DEG_SCF_FBW7_1	0.1667
p.Q250H	DO37471	SKCM	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1667
p.P238Q	DO48442	BLCA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.7035
p.H230N	DO229022	LICA	ICGC	PPTPPTT	DEG_SCF_FBW7_1	0.1111
p.G237D	SIDM01619	Endometrial Carcinoma	GDSC	PPTPPTT	DEG_SCF_FBW7_1	0.3056
p.G237D	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPTPPTT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons