DegronMD

Uniprot ID: P57073

Source protein: Transcription factor SOX-8

Source gene: SOX8

Class: DEG_SCF_FBW7_2

Location: 227:234

E3 ligase: FBXW7

DEGRON score: 0.9438

ASA_SCORE: 93.15

COIL: 0.882

CONS_SCORE: 0.3941

DSS_SCORE: 0.9161

HELIX: 0.1085

FCONS_SCORE: 1.1441

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T233M	TCGA-EA-A6QX	CESC	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	0.6312
p.T233M	DO48997	CESC	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.6312
p.P227L	TCGA-ZF-AA4U	BLCA	TCGA	PPTTPKTE	DEG_SCF_FBW7_2	0.6471
p.P227L	DO219085	BLCA	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.6471
p.P227L	ACH-001443	Thyroid Cancer	CCLE	PPTTPKTE	DEG_SCF_FBW7_2	0.6471
p.K241E	DO42673	UCEC	ICGC	PPTTPKTE	DEG_SCF_FBW7_2	0.25
p.P242L	SIDM00882	Breast Carcinoma	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	0.1111
p.P242L	HCC1419	breast	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	0.1111
p.G223R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	0.2222
p.G223R	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	0.2222
p.A240T	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	0.1667
p.A240T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPKTE	DEG_SCF_FBW7_2	0.1667
p.T230A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTTPKTE	DEG_SCF_FBW7_2	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons