DegronMD

Uniprot ID: O94855

Source protein: Protein transport protein Sec24D

Source gene: SEC24D

Class: ITCH

Location: 23:26

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9579

ASA_SCORE: 78.4

COIL: 0.9213

CONS_SCORE: 0.2498

DSS_SCORE: 0.6798

HELIX: 0.0273

FCONS_SCORE: 0.9462

RIG_SCORE: 0.5709

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G27E	TCGA-DF-A2KU	UCEC	TCGA	PPHY	ITCH	0.3056
p.G27E	DO223286	UCEC	ICGC	PPHY	ITCH	0.3056
p.H25Y	TCGA-ET-A25O	THCA	TCGA	PPHY	ITCH	0.6118
p.H25Y	DO38980	THCA	ICGC	PPHY	ITCH	0.6118
p.P17T	DO228978	LICA	ICGC	PPHY	ITCH	0.1667
p.P17T	DO229025	LICA	ICGC	PPHY	ITCH	0.1667
p.T35K	DO229015	LICA	ICGC	PPHY	ITCH	0.0833
p.H34Q	DO229026	LICA	ICGC	PPHY	ITCH	0.1111
p.G18R	DO228603	PRAD	ICGC	PPHY	ITCH	0.1944
p.Y29C	SIDM00491	Thyroid Gland Carcinoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00555	Glioblastoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00359	Colorectal Carcinoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM01439	Hepatocellular Carcinoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00169	Head and Neck Carcinoma	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	0.25
p.Y29C	SIDM00164	Biliary Tract Carcinoma	GDSC	PPHY	ITCH	0.25
p.P32S	SIDM00650	Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	0.1667
p.P32S	SIDM01681	Non-Cancerous	GDSC	PPHY	ITCH	0.1667
p.P32S	ACH-002362	Non-Cancerous	CCLE	PPHY	ITCH	0.1667
p.P23A	SIDM00929	Chondrosarcoma	GDSC	PPHY	ITCH	0.7503
p.P23A	ACH-000516	Bone Cancer	CCLE	PPHY	ITCH	0.7503
p.P23A	CAL-78	bone	COSMIC	PPHY	ITCH	0.7503
p.D24N	ACH-000112	Leukemia	CCLE	PPHY	ITCH	0.6932
p.D24N	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	PPHY	ITCH	0.6932
p.C18Y	HCC2998	large_intestine	COSMIC	PPHY	ITCH	0.1944

Drug responses associated with SEC24D mutations

All proteins holding degron of PPHY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15156	Zinc finger and BTB domain-containing protein 7B	ITCH	468:471	PPHY	ITCH,NEDD4	0.632	More...
O75081	Protein CBFA2T3	ITCH	339:342	PPHY	ITCH,NEDD4	0.9949	More...
O75618	Death effector domain-containing protein	ITCH	146:149	PPHY	ITCH,NEDD4	0.9035	More...
O75923	Dysferlin	ITCH	194:197	PPHY	ITCH,NEDD4	0.877	More...
O94855	Protein transport protein Sec24D	ITCH	23:26	PPHY	ITCH,NEDD4	0.9579	More...
P14866	Heterogeneous nuclear ribonucleoprotein L	ITCH	337:340	PPHY	ITCH,NEDD4	0.9935	More...
P56693	Transcription factor SOX-10	ITCH	366:369	PPHY	ITCH,NEDD4	0.9951	More...
P62072	Mitochondrial import inner membrane translocase subunit Tim10	ITCH	35:38	PPHY	ITCH,NEDD4	0.6439	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1704:1707	PPHY	ITCH,NEDD4	0.6355	More...
Q13227	G protein pathway suppressor 2	ITCH	194:197	PPHY	ITCH,NEDD4	0.9693	More...
Q13621	Solute carrier family 12 member 1	ITCH	42:45	PPHY	ITCH,NEDD4	0.9792	More...
Q6W2J9	BCL-6 corepressor	ITCH	249:252	PPHY	ITCH,NEDD4	0.7281	More...
Q6ZRV2	Protein FAM83H	ITCH	21:24	PPHY	ITCH,NEDD4	0.9628	More...
Q7Z4S6	Kinesin-like protein KIF21A	ITCH	1540:1543	PPHY	ITCH,NEDD4	0.7904	More...
Q86Y56	Dynein axonemal assembly factor 5	ITCH	335:338	PPHY	ITCH,NEDD4	0.6455	More...
Q8NC67	Neuropilin and tolloid-like protein 2	ITCH	395:398	PPHY	ITCH,NEDD4	0.9529	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	680:683	PPHY	ITCH,NEDD4	0.969	More...
Q8NFH8	RalBP1-associated Eps domain-containing protein 2	ITCH	200:203	PPHY	ITCH,NEDD4	0.9985	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	ITCH	339:342	PPHY	ITCH,NEDD4	0.7758	More...
Q9Y2G1	Myelin regulatory factor	ITCH	195:198	PPHY	ITCH,NEDD4	0.9944	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	ITCH	939:942	PPHY	ITCH,NEDD4	0.9973	More...
Q8TF68	Zinc finger protein 384	ITCH	46:49	PPHY	ITCH,NEDD4	0.9991	More...
Q96A35	39S ribosomal protein L24, mitochondrial	ITCH	16:19	PPHY	ITCH,NEDD4	0.837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPHY

Degron related mutations and impact score

Drug responses associated with SEC24D mutations

All proteins holding degron of PPHY