DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_SCF_FBW7_2

Location: 3402:3409

E3 ligase: FBXW7

DEGRON score: 0.7549

ASA_SCORE: 75.2625

COIL: 0.4856

CONS_SCORE: 0.375

DSS_SCORE: 0.5013

HELIX: 0.0084

FCONS_SCORE: 1.1414

RIG_SCORE: 0.7638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3418V	TCGA-19-1790	GBM	TCGA	VQVTPQLE	DEG_SCF_FBW7_2	0.0833
p.E3418V	DO12328	GBM	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	0.0833
p.V3402M	TCGA-F4-6808	COAD	TCGA	VQVTPQLE	DEG_SCF_FBW7_2	0.6097
p.V3402M	DO8946	COAD	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	0.6097
p.F3419L	DO44810	LICA	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	0.0556
p.P3395S	DO232761	PBCA	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	0.1389
p.P3395S	ACH-000423	Skin Cancer	CCLE	VQVTPQLE	DEG_SCF_FBW7_2	0.1389
p.S3412G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VQVTPQLE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SCF_FBW7_2	3402:3409	VQVTPQLE	FBXW7	0.7549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons