DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_SCF_FBW7_2

Location: 1893:1898

E3 ligase: FBXW7

DEGRON score: 0.7923

ASA_SCORE: 54.6

COIL: 0.4977

CONS_SCORE: 0.4396

DSS_SCORE: 0.6207

HELIX: 0.0067

FCONS_SCORE: 1.0235

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1883V	TCGA-E7-A8O8	BLCA	TCGA	PTPTLE	DEG_SCF_FBW7_2	0.0556
p.A1883V	DO219020	BLCA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.0556
p.A1883V	SIDM00854	Burkitt's Lymphoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	0.0556
p.A1883V	SIDM00828	Other Sarcomas	GDSC	PTPTLE	DEG_SCF_FBW7_2	0.0556
p.A1883V	SIDM01085	Bladder Carcinoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	0.0556
p.T1894M	TCGA-OR-A5LK	ACC	TCGA	PTPTLE	DEG_SCF_FBW7_2	0.7423
p.A1889T	DO233823	GACA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.2222
p.Q1906K	DO229019	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.1111
p.P1895T	DO229022	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.7031
p.T1896N	DO229037	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.5944
p.G1905N	DO222843	MELA	ICGC	PTPTLE	DEG_SCF_FBW7_2	0.1389
p.R1886C	SIDM01090	Colorectal Carcinoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	0.1389
p.R1886C	RKO	large_intestine	COSMIC	PTPTLE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SCF_FBW7_2	1893:1898	PTPTLE	FBXW7	0.7923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons