DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.9944

ASA_SCORE: 61.14

COIL: 0.6848

CONS_SCORE: 0.2214

DSS_SCORE: 0.5622

HELIX: 0.03

FCONS_SCORE: 0.8788

RIG_SCORE: 0.7432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E259D	TCGA-12-1088	GBM	TCGA	VETTS	DEG_SPOP_SBC_1	0.1667
p.E259D	DO13701	GBM	ICGC	VETTS	DEG_SPOP_SBC_1	0.1667
p.M263T	TCGA-95-7567	LUAD	TCGA	VETTS	DEG_SPOP_SBC_1	0.0556
p.M263T	DO25564	LUAD	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.S242I	TCGA-FS-A1Z0	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.1389
p.S242I	DO37431	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.1389
p.M263I	DO230309	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.M263I	SIDM00309	Mesothelioma	GDSC	VETTS	DEG_SPOP_SBC_1	0.0556
p.T252K	DO232849	NACA	ICGC	VETTS	DEG_SPOP_SBC_1	0.7306
p.I241M	ACH-000694	Esophageal Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	0.1111
p.F245L	ACH-000901	Lung Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	0.2222
p.P255S	ACH-001982	Metastasis	CCLE	VETTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	249:253	VETTS	SPOP	0.9944	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	151:155	VETTS	SPOP	0.9829	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9523:9527	VETTS	SPOP	0.6786	More...
Q96RL1	BRCA1-A complex subunit RAP80	DEG_SPOP_SBC_1	22:26	VETTS	SPOP	0.9963	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	244:248	VETTS	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons