DegronMD

Uniprot ID: Q9HCK1

Source protein: DBF4-type zinc finger-containing protein 2

Source gene: ZDBF2

Class: DEG_SPOP_SBC_1

Location: 244:248

E3 ligase: SPOP

DEGRON score: 0.995

ASA_SCORE: 80.12

COIL: 0.7296

CONS_SCORE: 0.5564

DSS_SCORE: 0.5942

HELIX: 0.0838

FCONS_SCORE: 1.0506

RIG_SCORE: 0.6824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S248L	TCGA-93-8067	LUAD	TCGA	VETTS	DEG_SPOP_SBC_1	0.7667
p.S248L	DO25113	LUAD	ICGC	VETTS	DEG_SPOP_SBC_1	0.7667
p.P240R	TCGA-CC-A8HT	LIHC	TCGA	VETTS	DEG_SPOP_SBC_1	0.2222
p.P240R	DO52187	LIHC	ICGC	VETTS	DEG_SPOP_SBC_1	0.2222
p.S250L	TCGA-EE-A20C	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	TCGA-FR-A726	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	TCGA-WE-A8K4	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	DO222775	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	DO48665	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	DO47665	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.S250L	DO51281	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.H254Q	TCGA-XQ-A8TA	PRAD	TCGA	VETTS	DEG_SPOP_SBC_1	0.1667
p.H254Q	DO223662	PRAD	ICGC	VETTS	DEG_SPOP_SBC_1	0.1667
p.H254R	DO20604	KIRC	ICGC	VETTS	DEG_SPOP_SBC_1	0.1667
p.Y251N	DO220855	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	0.25
p.Y251I	DO220855	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	0.25
p.P238S	DO222753	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	249:253	VETTS	SPOP	0.9944	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	151:155	VETTS	SPOP	0.9829	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9523:9527	VETTS	SPOP	0.6786	More...
Q96RL1	BRCA1-A complex subunit RAP80	DEG_SPOP_SBC_1	22:26	VETTS	SPOP	0.9963	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	244:248	VETTS	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons