DegronMD - Q96RL1(UIMC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S27Y	TCGA-13-0893	OV	TCGA	VETTS	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.75
p.S27Y	DO29002	OV	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation blocking phosphorylation signal	0.75
p.Q268R	TCGA-BS-A0UJ	UCEC	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1667
p.Q268R	DO42745	UCEC	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1667
p.S250C	TCGA-DI-A1BU	UCEC	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2222
p.S250C	DO42023	UCEC	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2222
p.S14F	TCGA-EB-A3XF	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S14F	TCGA-FD-A3SS	BLCA	TCGA	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S14F	DO737	BLCA	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S14F	DO37437	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.E13K	TCGA-EO-A3B0	UCEC	TCGA	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.E13K	DO219773	UCEC	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.P464L	TCGA-FW-A3R5	SKCM	TCGA	SRDILDGVR	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.P464L	DO37406	SKCM	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.2778
p.V247F	TCGA-G9-6371	PRAD	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1389
p.V247F	DO36314	PRAD	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1389
p.E461D	DO222798	COCA	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1944
p.Q248K	DO229029	LICA	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1667
p.R34S	DO229041	LICA	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S14Y	DO46368	OV	ICGC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.S463A	DO51965	PRAD	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	466:474	Mutation blocking phosphorylation signal	0.6944
p.S477F	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	SRDILDGVR	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.R14C	SNU-175	large intestine	COSMIC	VETTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.A252T	IGROV-1	ovary	COSMIC	SRHCLPTLA	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2778

Kaplan plot for UIMC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UIMC1

UniProt ID: Q96RL1

Entrez ID: 51720

Protein name: BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UIMC1 in