DegronMD

Uniprot ID: Q96RL1

Source protein: BRCA1-A complex subunit RAP80

Source gene: UIMC1

Class: DEG_APCC_DBOX_1

Location: 254:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9954

ASA_SCORE: 84.3556

COIL: 0.7526

CONS_SCORE: 0.5375

DSS_SCORE: 0.4158

HELIX: 0.1368

FCONS_SCORE: 1.0507

RIG_SCORE: 0.8018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q268R	TCGA-BS-A0UJ	UCEC	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	0.1667
p.Q268R	DO42745	UCEC	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	0.1667
p.S250C	TCGA-DI-A1BU	UCEC	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	0.2222
p.S250C	DO42023	UCEC	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	0.2222
p.V247F	TCGA-G9-6371	PRAD	TCGA	SRHCLPTLA	DEG_APCC_DBOX_1	0.1389
p.V247F	DO36314	PRAD	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	0.1389
p.Q248K	DO229029	LICA	ICGC	SRHCLPTLA	DEG_APCC_DBOX_1	0.1667
p.A252T	IGROV-1	ovary	COSMIC	SRHCLPTLA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RL1	BRCA1-A complex subunit RAP80	DEG_APCC_DBOX_1	254:262	SRHCLPTLA	APC,CDC20,FZR1	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons