DegronMD

Uniprot ID: Q96RL1

Source protein: BRCA1-A complex subunit RAP80

Source gene: UIMC1

Class: DEG_SPOP_SBC_1

Location: 22:26

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 99.52

COIL: 0.8078

CONS_SCORE: 0.2453

DSS_SCORE: 0.4362

HELIX: 0.1684

FCONS_SCORE: 0.7411

RIG_SCORE: 0.7351

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27Y	TCGA-13-0893	OV	TCGA	VETTS	DEG_SPOP_SBC_1	0.75
p.S27Y	DO29002	OV	ICGC	VETTS	DEG_SPOP_SBC_1	0.75
p.S14F	TCGA-EB-A3XF	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.1111
p.S14F	TCGA-FD-A3SS	BLCA	TCGA	VETTS	DEG_SPOP_SBC_1	0.1111
p.S14F	DO737	BLCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.S14F	DO37437	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.E13K	TCGA-EO-A3B0	UCEC	TCGA	VETTS	DEG_SPOP_SBC_1	0.0833
p.E13K	DO219773	UCEC	ICGC	VETTS	DEG_SPOP_SBC_1	0.0833
p.R34S	DO229041	LICA	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.S14Y	DO46368	OV	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.R14C	SNU-175	large_intestine	COSMIC	VETTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	249:253	VETTS	SPOP	0.9944	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	151:155	VETTS	SPOP	0.9829	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9523:9527	VETTS	SPOP	0.6786	More...
Q96RL1	BRCA1-A complex subunit RAP80	DEG_SPOP_SBC_1	22:26	VETTS	SPOP	0.9963	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	244:248	VETTS	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons