DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 151:155

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 97.32

COIL: 0.8818

CONS_SCORE: 0

DSS_SCORE: 0.5176

HELIX: 0.0158

FCONS_SCORE: 0

RIG_SCORE: 0.7404

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E143Q	TCGA-18-3410	LUSC	TCGA	VETTS	DEG_SPOP_SBC_1	0.1111
p.E143Q	DO26456	LUSC	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.T150I	TCGA-BF-AAOX	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.75
p.T150I	DO223907	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.75
p.P165H	TCGA-D3-A2JD	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.0556
p.P165H	DO37543	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.E143K	TCGA-FW-A3R5	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.1111
p.E143K	DO37406	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.1111
p.P157T	DO233767	GACA	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.P157T	DO229027	LICA	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.E160K	SIDM01722	Non-Cancerous	GDSC	VETTS	DEG_SPOP_SBC_1	0.1944
p.E160K	SIDM00174	Head and Neck Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.1944
p.E160K	SIDM00151	Ovarian Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.1944
p.E160K	SIDM00815	Ovarian Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.1944
p.K142R	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.1944
p.K142R	ACH-000781	Lung Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	0.1944
p.K142R	NCI-H2023	lung	COSMIC	VETTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	249:253	VETTS	SPOP	0.9944	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	151:155	VETTS	SPOP	0.9829	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9523:9527	VETTS	SPOP	0.6786	More...
Q96RL1	BRCA1-A complex subunit RAP80	DEG_SPOP_SBC_1	22:26	VETTS	SPOP	0.9963	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	244:248	VETTS	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons