DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9523:9527

E3 ligase: SPOP

DEGRON score: 0.6786

ASA_SCORE: 89.3

COIL: 0.7356

CONS_SCORE: 0

DSS_SCORE: 0.4993

HELIX: 0.023

FCONS_SCORE: 0

RIG_SCORE: 0.7427

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H9522D	TCGA-34-8455	LUSC	TCGA	VETTS	DEG_SPOP_SBC_1	0.3056
p.H9522D	DO50095	LUSC	ICGC	VETTS	DEG_SPOP_SBC_1	0.3056
p.H9513Y	TCGA-AD-6895	COAD	TCGA	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513Y	DO8938	COAD	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.E9531K	TCGA-D3-A3C7	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9531K	TCGA-YG-AA3N	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9531K	DO47569	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9531K	DO51298	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9531K	SIDM00933	Breast Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9531K	SIDM00875	Breast Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.2222
p.E9524K	TCGA-D9-A6EC	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.591
p.E9524K	DO50291	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.591
p.P9537T	TCGA-DU-8168	LGG	TCGA	VETTS	DEG_SPOP_SBC_1	0.0556
p.P9537T	DO22367	LGG	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.S9521F	TCGA-EB-A550	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.2778
p.S9521F	DO229453	SKCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.S9521F	DO47265	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.2778
p.H9513P	TCGA-ER-A193	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513P	DO47368	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.E9530Q	TCGA-YY-A8LH	PAAD	TCGA	VETTS	DEG_SPOP_SBC_1	0.25
p.E9530Q	DO50273	PAAD	ICGC	VETTS	DEG_SPOP_SBC_1	0.25
p.H9513Q	DO230334	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513Q	DO227999	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513Q	DO229003	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513Q	DO229505	LAML	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9513Q	DO230529	LUSC	ICGC	VETTS	DEG_SPOP_SBC_1	0.0556
p.H9522R	DO222762	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.3056
p.V9514I	DO222849	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	0.0833
p.A9520S	DO233941	GACA	ICGC	VETTS	DEG_SPOP_SBC_1	0.25
p.L9532P	DO27781	MALY	ICGC	VETTS	DEG_SPOP_SBC_1	0.1944
p.S9534F	DO222409	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	0.1389
p.E9516K	SIDM00007	Other Solid Cancers	GDSC	VETTS	DEG_SPOP_SBC_1	0.1389
p.E9516K	ACH-001550	Skin Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	0.1389
p.E9516K	MCC13	skin	COSMIC	VETTS	DEG_SPOP_SBC_1	0.1389
p.A9520T	SIDM00854	Burkitt's Lymphoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.25
p.A9520T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.25
p.A9520T	SIDM00673	Breast Carcinoma	GDSC	VETTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	249:253	VETTS	SPOP	0.9944	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	151:155	VETTS	SPOP	0.9829	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9523:9527	VETTS	SPOP	0.6786	More...
Q96RL1	BRCA1-A complex subunit RAP80	DEG_SPOP_SBC_1	22:26	VETTS	SPOP	0.9963	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	244:248	VETTS	SPOP	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VETTS