DegronMD

Uniprot ID: Q96RL1

Source protein: BRCA1-A complex subunit RAP80

Source gene: UIMC1

Class: DEG_APCC_DBOX_1

Location: 466:474

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 86.7556

COIL: 0.6846

CONS_SCORE: 0.4875

DSS_SCORE: 0.4033

HELIX: 0.1272

FCONS_SCORE: 1.0938

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P464L	TCGA-FW-A3R5	SKCM	TCGA	SRDILDGVR	DEG_APCC_DBOX_1	0.2778
p.P464L	DO37406	SKCM	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	0.2778
p.E461D	DO222798	COCA	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	0.1944
p.S463A	DO51965	PRAD	ICGC	SRDILDGVR	DEG_APCC_DBOX_1	0.6944
p.S477F	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	SRDILDGVR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RL1	BRCA1-A complex subunit RAP80	DEG_APCC_DBOX_1	466:474	SRDILDGVR	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons