DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: DEG_APCC_DBOX_1

Location: 2776:2784

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8988

ASA_SCORE: 56.2

COIL: 0.4969

CONS_SCORE: 0.4038

DSS_SCORE: 0.5513

HELIX: 0.0047

FCONS_SCORE: 0.8554

RIG_SCORE: 0.6685

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2775D	TCGA-2W-A8YY	CESC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.3056
p.G2775D	DO223732	CESC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.3056
p.G2775S	TCGA-2W-A8YY	CESC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.3056
p.G2775S	DO223732	CESC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.3056
p.R2794P	TCGA-90-A59Q	LUSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.R2794P	DO50103	LUSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.C2793F	TCGA-90-A59Q	LUSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.0833
p.C2793F	DO50103	LUSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0833
p.R2794Q	TCGA-AP-A0LM	UCEC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.R2794Q	DO43306	UCEC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.R2794Q	SIDM01147	Gastric Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.L2767I	TCGA-AP-A1DK	UCEC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.0833
p.L2767I	DO42033	UCEC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0833
p.R2777L	TCGA-CN-A63W	HNSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.8428
p.R2777L	TCGA-L9-A7SV	LUAD	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.8428
p.R2777L	DO49031	HNSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.8428
p.R2777L	DO49875	LUAD	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.8428
p.R2794W	TCGA-CV-6955	HNSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.R2794W	DO14338	HNSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.0556
p.Q2772H	TCGA-D3-A1Q3	SKCM	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.2222
p.R2779W	TCGA-ED-A66Y	LIHC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.7523
p.R2779W	DO230346	COCA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.7523
p.R2779W	DO44874	LIHC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.7523
p.S2769G	TCGA-HU-A4H8	STAD	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.1389
p.S2769G	DO47869	STAD	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1389
p.P2768S	TCGA-OD-A75X	SKCM	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	0.1111
p.P2768S	DO48601	SKCM	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1111
p.D2787E	DO225090	BRCA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.25
p.H2781N	DO229032	LICA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	0.6312
p.S2788L	SIDM00615	Hepatocellular Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.2222
p.S2788L	ACH-000217	Liver Cancer	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	0.2222
p.S2788L	JHH-6	liver	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	0.2222
p.R2774H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.2778
p.R2774H	ACH-002256	Leukemia	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	0.2778
p.R2774H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	0.2778
p.R2777Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.7329
p.R2777Q	SIDM01336	Glioblastoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.7329
p.Y2791C	SIDM01045	Endometrial Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1389
p.Y2791C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	0.1389
p.Y2791C	EN	endometrium	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1389
p.P2785L	SIDM00254	Neuroblastoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.3056
p.V2792M	SIDM01228	Melanoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1111
p.V2792M	CHL-1	skin	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRLRLHHVS

Degron related mutations and impact score

Drug responses associated with HSPG2 mutations

All proteins holding degron of SRLRLHHVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_APCC_DBOX_1	2776:2784	SRLRLHHVS	APC,CDC20,FZR1	0.8988	More...